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Web Date: September 19, 2012

Tool May Aid Biosynthetic Reverse Engineering

Chemical Biology: Researchers reversibly tag a protein essential for the assembly of complex molecules in biological cells
Department: Science & Technology
News Channels: Biological SCENE
Keywords: protein engineering, fatty acid synthesis, biofuels

Some of nature’s most complex molecules are made by cellular factories that rely on a protein called ACP to shuttle growing molecules along biological assembly lines. Now, chemists in California are reporting the first method for reversibly labeling this protein.

The technique could help researchers learn how to successfully rewire cellular factories—such as those involved in polyketide, nonribosomal protein, and fatty acid syntheses—to allow construction of new, economically relevant products, such as drugs or biofuels, . . .

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Chemical & Engineering News
ISSN 0009-2347
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