Volume 91 Issue 10 | p. 8 | News of The Week
Issue Date: March 11, 2013

Antibiotics Don’t Kill With Reactive Oxygen Species

Microbiology: Reactive molecules aren’t weapons; finding casts doubt on drug development approach
Department: Science & Technology
News Channels: Biological SCENE
Keywords: antibiotics, cell death, reactive oxygen species, ROS

Just when it seemed that scientists had a handle on how antibiotics kill bacteria and how their power could be amplified, new evidence has emerged that casts doubt on that approach.

In 2007, James J. Collins and coworkers at Boston University presented evidence that all bacteria-killing antibiotics do their jobs by inducing the formation of reactive oxygen species (ROS) (C&EN, Sept. 10, 2007, page 8; Cell, . . .

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