Volume 91 Issue 15 | p. 8 | News of The Week
Issue Date: April 15, 2013

Rapid Route To Pactamycin

Natural Products: Shortened synthesis could lead to drug candidates based on the compound
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: pactamycin, symmetry, natural products

The potent natural product pactamycin has antitumor, antimicrobial, antiviral, and anti­protozoal properties. It could be a great drug if it weren’t also toxic to people. Now the compound has been prepared via a new route that slashes the number of reactions required to make the molecule by more than half (Science, DOI: 10.1126/science.1234756) and suggests a way to make analogs that overcome its toxicity.

Pactamycin was first isolated from the bacterium Streptomyces pactum . . .

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