Issue Date: April 15, 2013
Rapid Route To Pactamycin
The potent natural product pactamycin has antitumor, antimicrobial, antiviral, and antiprotozoal properties. It could be a great drug if it weren’t also toxic to people. Now the compound has been prepared via a new route that slashes the number of reactions required to make the molecule by more than half (Science, DOI: 10.1126/science.1234756) and suggests a way to make analogs that overcome its toxicity.
Pactamycin was first isolated from the bacterium Streptomyces pactum . . .
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