Issue Date: July 29, 2013
Branching Out In Different Ways
An important tool has been missing from the carbohydrate chemist’s toolbox: the ability to easily synthesize libraries of asymmetrically branched N-linked glycans. Without this tool, chemists haven’t been able to use these common molecules—often attached to proteins on cell surfaces—to screen drug candidates and explore ways cells communicate.
Now, a strategy developed by Geert-Jan Boons and coworkers at the Complex Carbohydrate Research Center at the University of Georgia changes that. The work . . .
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