Branching Out In Different Ways | July 29, 2013 Issue - Vol. 91 Issue 30 | Chemical & Engineering News
Volume 91 Issue 30 | p. 9 | News of The Week
Issue Date: July 29, 2013

Branching Out In Different Ways

Carbohydrate Chemistry: New synthetic strategy leads to asymmetrically branched N-glycans
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: N-linked glycans, carbohydrates

An important tool has been missing from the carbohydrate chemist’s toolbox: the ability to easily synthesize libraries of asymmetrically branched N-linked glycans. Without this tool, chemists haven’t been able to use these common molecules—often attached to proteins on cell surfaces—to screen drug candidates and explore ways cells communicate.

Now, a strategy developed by Geert-Jan Boons and coworkers at the Complex Carbohydrate Research Center at the University of Georgia changes that. The work . . .

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