Volume 91 Issue 31 | p. 31 | Concentrates
Issue Date: August 5, 2013

New Twist On Chiral Fluorination

Chiral fluorinating reagent facilitates a tandem fluorination-cyclization process for synthesizing compounds with quaternary C–F stereocenters
Department: Science & Technology
News Channels: Organic SCENE
Keywords: fluorination, Selectfluor, chiral synthesis

Recent advances in organofluorine chemistry have made fluorinated compounds—widely sought as pharmaceuticals and agrochemicals—more readily available than ever before. One of the final frontiers is developing general methods for selectively making compounds with chiral C–F bonds. A European research team has now developed a chiral version of a popular fluorinating reagent that could help streamline such efforts (Angew. Chem. Int. Ed. 2013, DOI: 10.1002/anie.201304845). Véronique . . .

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