Volume 91 Issue 33 | p. 25 | Concentrates
Issue Date: August 19, 2013

New Sensor Tracks Methylglyoxal

With improvement, fluorescent molecule could allow study of real-time processing of key cell metabolite
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE, JACS In C&EN
Keywords: methylglyoxal, fluorescence sensor, living cells

Methylglyoxal (MGO), a ubiquitous metabolite produced by living cells, plays a poorly understood role in numerous diseases, such as diabetes, and is implicated in chemotherapy resistance. Until now, there hasn’t been a good way to monitor MGO in living cells. David A. Spiegel and Tina Wang of Yale University and colleagues have synthesized a molecule that selectively attaches to MGO and renders the complex fluorescent (J. Am. Chem. Soc. 2013, DOI: . . .

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