Issue Date: September 9, 2013
New Route To On-Off Gene Control
A bacterial immune system component called CRISPR/Cas9 has been widely adopted in the past year for modifying genes and turning them on or off to study gene expression and develop new therapies. Timothy K. Lu and coworkers at MIT have now succeeded in both activating and repressing genes with the same Cas9 construct, just slightly modified by a customized guide RNA in each case to hit a different spot on a . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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