Volume 91 Issue 4 | p. 9 | News of The Week
Issue Date: January 28, 2013

Ringing In New Drug Candidates

Synthesis: Tweaking natural products’ rings and functional groups could create better compound libraries
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Organic SCENE
Keywords: natural products, diversity, drug discovery

Most new drugs are discovered by screening compound collections, or libraries, for worthy candidates. But many such collections consist primarily of molecules that do not possess the structural, stereochemical, and functional complexity equivalent to that of natural products. A new method of constructing natural-product-like compound collections aims to address that deficiency (Nat. Chem., DOI: 10.1038/nchem.1549).

Natural products are among the . . .

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