Antidepressant Binding Findings | October 21, 2013 Issue - Vol. 91 Issue 42 | Chemical & Engineering News
Volume 91 Issue 42 | p. 5 | News of The Week
Issue Date: October 21, 2013

Antidepressant Binding Findings

Structural Biology: Four drug types bind in a similar way, but nonhuman model raises questions
Department: Science & Technology
News Channels: Biological SCENE, Analytical SCENE
Keywords: antidepressants, crystallography, structural biology, neurotransmitters

Antidepressants target transporter proteins in the human brain that regulate the levels of neurotransmitters such as serotonin and dopamine. The drugs block the transporters from removing neurotransmitters from nerve-cell synapses, thus having a psychoactive effect. But because these human proteins have been difficult to crystallize, information about the exact way they bind to the drugs has been limited.

New findings reported on Oct. 13 suggest that four types of antidepressants bind with transporter proteins in . . .

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