Volume 91 Issue 46 | p. 8 | News of The Week
Issue Date: November 18, 2013

Gene Silencing By Design

Drug Discovery: Tweaking short interfering RNAs improves their ability to turn off bad genes
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Analytical SCENE, JACS In C&EN
Keywords: Argonaute, RNAi, RNA interference, siRNA, short interfering RNA, structure-based design

When new protein structures are reported, it’s often claimed they could lead to the design of therapeutic agents that interact with the proteins more effectively. A new study on short interfering RNAs (siRNAs) actually demonstrates such a result.

Last year, two research groups determined crystal structures of the human version of Argonaute—a protein in the RNA interference (RNAi) pathway that cells use to turn off target genes. siRNAs activate RNAi in cells by binding to . . .

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