Volume 91 Issue 48 | p. 29 | Concentrates
Issue Date: December 2, 2013

Protein Structure From Scratch

Free-electron laser X-ray source provides sufficiently accurate data to solve protein structures without need for additional information
Department: Science & Technology
Keywords: crystallography, protein structure, lysozyme, free-electron lasers

Free-electron lasers (FELs), which produce extremely intense, ultrashort X-ray pulses, have previously been used to determine structures of microscale protein crystals. But so far, all of the crystal structures solved this way have required the addition of data from already known and related structures. Now, researchers have used only FEL data to solve a known structure, lysozyme, at 2.1-Å resolution (Nature 2013, DOI: . . .

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