Copper Complex Lights Up Alzheimer’s Lesions | Chemical & Engineering News
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Web Date: October 8, 2013

Copper Complex Lights Up Alzheimer’s Lesions

Medical Imaging: Copper-coordinated ligands bind to amyloid-β plaques, providing long-lived radioisotopes for brain imaging
Department: Science & Technology | Collection: Life Sciences
News Channels: Analytical SCENE, Biological SCENE, JACS In C&EN
Keywords: Alzheimer’s disease, brain imaging, amyloid plaques, radiolabeling

In the last decade, doctors have started to use small-molecule tracers to detect clumped protein plaques in the brains of living Alzheimer’s disease patients. Last year, the Food and Drug Administration approved a fluorine-18-based compound that binds to the plaques and produces a signal detectable through positron emission tomography (PET). Now Australian researchers present a new copper complex that does the same but has a longer half-life (J. Am. Chem. . . .

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