Chemists Report First Inhibitors Of AMPylation | Chemical & Engineering News
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Web Date: December 5, 2013

Chemists Report First Inhibitors Of AMPylation

Chemical Biology: Molecules blocking bacterial enzymes that transfer AMP could lead to new antibiotics
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Organic SCENE
Keywords: antibiotic, food poisoning, adenosine triphosphate

When Vibrio parahemolyticus, the bacterium responsible for most cases of food poisoning, infects a host, it injects a cocktail of proteins into the host’s cells. One of these proteins, VopS, transfers adenosine monophosphate (AMP) from adenosine triphosphate (ATP) to the host’s proteins, which disrupts signaling pathways, causing the cells to morph in shape and eventually die. Now researchers have identified the first inhibitors of VopS, which could serve as a . . .

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