Web Date: December 5, 2013
Chemists Report First Inhibitors Of AMPylation
When Vibrio parahemolyticus, the bacterium responsible for most cases of food poisoning, infects a host, it injects a cocktail of proteins into the host’s cells. One of these proteins, VopS, transfers adenosine monophosphate (AMP) from adenosine triphosphate (ATP) to the host’s proteins, which disrupts signaling pathways, causing the cells to morph in shape and eventually die. Now researchers have identified the first inhibitors of VopS, which could serve as a . . .
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