Unlocked Nucleic Acids Help Silence Genes Selectively | Chemical & Engineering News
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Web Date: December 11, 2013

Unlocked Nucleic Acids Help Silence Genes Selectively

Molecular Medicine: Researchers incorporated flexible synthetic nucleic acids into silencing RNAs to selectively inhibit expression of a mutant Huntington’s gene
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: siRNA, small interfering RNA, Huntington’s disease, trinucleotide repeat disorders, unlocked nucleic acids

Some biologists have long hoped that small pieces of RNA that silence genes could help wipe out genetic diseases. But developing nucleic acid medications with good drug properties, such as selectivity, has proven difficult. Researchers have now added a new, improved weapon to the silencing arsenal: RNAs containing flexible synthetic nucleic acids. These RNAs selectively and potently inhibit the expression of the mutant genes associated with Huntington’s disease . . .

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