Volume 92 Issue 11 | p. 9 | News of The Week
Issue Date: March 17, 2014

Fast-Flow Peptides

Lab Automation: MIT chemists devise a continuous reactor for speedy solid-phase synthesis
Department: Science & Technology | Collection: Green Chemistry, Life Sciences
News Channels: Biological SCENE, Organic SCENE
Keywords: peptide synthesis, flow reactor, microwave synthesis, synthetic protein

Solid-phase peptide synthesis is an indispensable method for constructing natural and modified peptide sequences. But the multistep process, even when automated, is extremely time-consuming for the relatively small amount of peptide generated. For example, a milligram-scale synthesis of a peptide 20 amino acids long can take 24 hours or longer to complete.

An MIT research team including Mark D. Simon, Klavs F. Jensen, and Andrea Adamo and led by

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