Volume 92 Issue 12 | pp. 34-35
Issue Date: March 24, 2014

Dynamics Determine Enzyme Selectivity

Biosynthetic protein may steer a reaction after the transition state to home in on a single natural product
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: selectivity, bifurcation

When chemists—or enzymes—try to create only one of a few possible products of a reaction, their strategy typically involves stabilizing the transition state that leads to the desired compound. In some cases, however, the route down an energy surface from a single transition state forks and forks again, leading to multiple products with no intermediate stops along the way.

That’s the case explored in a recent investigation of the biosynthesis of the tricyclic diterpene miltiradiene, . . .

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