Volume 92 Issue 14 | p. 35 | Concentrates
Issue Date: April 7, 2014

Cellular Tug-Of-War

Protein receptors that decorate breast cancer cells exert surprisingly high forces on their binding partners
Department: Science & Technology
Keywords: mechanics, force, microscopy, biotin, streptavidin, integrin

Using a technique they invented called molecular-tension-based fluorescence microscopy, researchers at Emory University have observed that a cell receptor called integrin forms a surprisingly strong attachment to one of its usual peptide binding partners (Biophys. J. 2014, DOI: 10.1016/j.bpj.2014.01.049). How cells respond to external forces and chemical cues is something researchers—particularly those designing drugs targeted at tumor cells—have long been trying to understand . . .

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