Volume 92 Issue 14 | p. 35 | Concentrates
Issue Date: April 7, 2014

New Epigenetic Mark Linked To Sperm Production

Researchers discover a posttranslational modification for histone’s lysine groups that helps differentiate germ cells into sperm
Department: Science & Technology
Keywords: histone, lysine, posttranslational modification, epigenetics

Scientists have discovered a new type of chemical decoration on lysine groups of histone proteins—around which DNA in a nucleus is wound—that helps differentiate male germ cells into sperm. That’s just one confirmed role for lysine 2-hydroxyisobutyrylation (Khib), which was identified by a team led by Saadi Khochbin of Joseph Fourier University, in France, and Yingming Zhao of the University of Chicago (Nat. Chem. Biol. 2014, DOI: . . .

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