Volume 92 Issue 17 | p. 26 | Concentrates
Issue Date: April 28, 2014

Diazoalkane Expands Fluorine Focus On Ethyl Groups

New reagent helps broaden the scope of fluorination reactions
Department: Science & Technology | Collection: Green Chemistry
News Channels: Organic SCENE, JACS In C&EN
Keywords: fluorine chemistry, organometallics, drug discovery, organic synthesis

Developing new methods for introducing fluorine into complex organic molecules has been all the rage during the past few years. Researchers preparing drug candidates and crop protection chemicals typically seek to add a single fluorine atom or trifluoromethyl group and now have myriad ways to do so. But methods for adding longer, more lipophilic perfluoroalkyl groups such as penta­fluoroethyl, –C2F5, to complex molecules are relatively scarce. The approaches tend to be . . .

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