Issue Date: April 28, 2014
Diazoalkane Expands Fluorine Focus On Ethyl Groups
Developing new methods for introducing fluorine into complex organic molecules has been all the rage during the past few years. Researchers preparing drug candidates and crop protection chemicals typically seek to add a single fluorine atom or trifluoromethyl group and now have myriad ways to do so. But methods for adding longer, more lipophilic perfluoroalkyl groups such as pentafluoroethyl, –C2F5, to complex molecules are relatively scarce. The approaches tend to be . . .
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