Volume 92 Issue 19 | p. 28 | Concentrates
Issue Date: May 12, 2014

Double-Crossed Pyridines

Chemists develop and combine new transition-metal-free cross-coupling reactions to prepare polyfunctional pyridines
Department: Science & Technology
News Channels: Organic SCENE
Keywords: cross-coupling, Lewis acid, alkyllithium, Grignard reagent

Palladium- and nickel-catalyzed cross-coupling reactions are at the top of the list for many chemists when it comes to functionalizing aromatic rings. But there are other ways. Exploring the options, a team led by Paul Knochel of Ludwig Maximilian University of Munich, in Germany, has developed a pair of transition-metal-free cross-couplings facilitated by the Lewis acid adduct BF3•O(CH2CH3)2 (Angew. Chem. Int. Ed. 2014, DOI: . . .

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