Volume 92 Issue 21 | p. 40 | Concentrates
Issue Date: May 26, 2014

Diabetes-Related Enzyme Modulates Insulin, Amylin, And Glucagon

Inhibition of insulin-degrading enzyme by synthetic macrocycle suggests strategy for type 2 diabetes treatment
Department: Science & Technology
News Channels: Biological SCENE
Keywords: diabetes, enzyme, inhibitors

Scientists have wondered for decades whether slowing the degradation of insulin in the body might be a way to treat type 2 diabetes. The gene that encodes a zinc metalloprotease called insulin-degrading enzyme (IDE) was identified several years ago as a diabetes susceptibility gene. David R. Liu and Alan Saghatelian of Harvard University and coworkers have now discovered from a DNA-templated macrocycle library a potent, highly selective, and . . .

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