Volume 92 Issue 23 | pp. 12-15
Issue Date: June 9, 2014

Cover Story

Complex Carbohydrates

Improvements in methods, standards, and software are still needed to move mass spec analysis of carbohydrates into the mainstream
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: spectrometry, carbohydrates, glycans, glycoproteomics, glycosaminoglycans

Carbohydrates are ubiquitous. They densely carpet cell surfaces. They are the main component of the extracellular matrix that surrounds cells. They are involved in many aspects of cell-cell ­communication.

Glycans, a type of carbohydrate, are “the first thing a signaling molecule encounters when it contacts a cell,” says Robert J. Linhardt, a biochemist at Rensselaer Polytechnic Institute who studies carbohydrate structure and function. “They’re the first thing a virus encounters when it . . .

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