Volume 92 Issue 30 | p. 32 | Concentrates
Issue Date: July 28, 2014

Forcing Reactants To Click

By pushing alkyne-coated elastomeric tips onto an azide-covered surface, chemists induce the Huisgen reaction and quantify the force needed to do so
Department: Science & Technology
News Channels: Organic SCENE, JACS In C&EN
Keywords: malaria, FTIR, spectroscopy, imaging, synchrotron

There is a disturbance in the force-induced reaction community. Chemists disagree as to whether it’s possible to spur on the Huisgen reaction—the most popular of the so-called click reactions—by forcing the azide and alkyne reactants into contact with each other. Seeking to clear up the matter, researchers led by Adam B. Braunschweig of the University of Miami created azide-coated monolayers on a surface of gold-covered glass and then used arrays of elastomeric . . .

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