Volume 92 Issue 4 | p. 25 | Concentrates
Issue Date: January 27, 2014

Enzyme Catalysis Illustrated

Bowl-to-bowl inversion process for corannulene provides a simple model for studying catalyzed conformational changes
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: corannulene, ExBox, enxyme catalysis, molecular modeling

A tenet of enzyme catalysis is that the catalyst should bind the transition state more strongly than the ground state. Although the principle is widely applied, particularly with catalytic antibodies, chemists have lacked a simple, well-characterized model to illustrate this seminal system. Jay S. Siegel at China’s Tianjin University, J. Fraser Stoddart of Northwestern University, and colleagues report in Nature Chemistrythat they’ve designed a representative reaction that . . .

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