Volume 92 Issue 40 | p. 8 | News of The Week
Issue Date: October 6, 2014

Aptamers For Small Molecules

Biosensors: Strategy for designing custom oligonucleotides could lead to biosensors for small metabolites
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: aptamers, nucleic acids, biosensors, small molecules

Aptamers—folded oligonucleotides designed to bind a ligand of interest—are often used to make biosensors. But finding high-affinity, selective aptamers for very small molecules such as simple sugars or amino acids can be tough because such molecules often lack functional groups for the aptamers to grab onto. Researchers at Columbia University have found a way around this problem. The resulting aptamers could be used to make sensitive biosensors that can, for example, detect the low concentrations . . .

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