Issue Date: October 20, 2014
Proton Source Guides Two-Way Selectivity
Chemists have found an unusual switch in enantioselectivity––from 92% of one enantiomer to 91% of the other––by changing the proton source in a reaction used to synthesize isoflavanones (Chem. Eur. J. 2014, DOI: 10.1002/chem.201405246). According to the researchers, this is the first example of dual stereocontrol in an asymmetric protonation reaction. The observation could ease the synthesis of customized isoflavanones, which are plant metabolites . . .
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