Volume 92 Issue 49 | pp. 30-31 | Concentrates
Issue Date: December 8, 2014

Potent X-rays Reveal Protein Contortions

New time-resolved crystallography approach could yield additional insight into reaction mechanisms
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: X-ray, diffraction, femotsecond, crystallography, structural biology, free-electron laser

Ultrashort, intense X-ray bursts have been used in the past few years to glean structural information from streams of protein nanocrystals, soot, water droplets, and even single molecules. The same approach can also yield structures of short-lived protein reaction intermediates at near-atomic resolution, reports a team led by Marius Schmidt of the University of Wisconsin, Milwaukee (Science 2014, DOI: 10.1126/science.1259357). Researchers have obtained time-resolved crystal structures using traditional synchrotron . . .

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