Issue Date: February 3, 2014 | Web Date: January 30, 2014
NMR Structures Get Sharper With Rosetta
For determining protein structure, X-ray crystallography typically beats nuclear magnetic resonance spectroscopy for accuracy. But chemists now report that, in most cases, NMR structures refined by a computer program called Rosetta match more closely with those determined by crystallography than do unrefined ones.
Although X-ray crystallography is the gold standard for solving protein structures, not all proteins crystallize well. Also, floating in solution could be a more realistic condition for proteins than sitting in a . . .
To view the rest of this content, please log in with your ACS ID.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society