Issue Date: February 3, 2014 | Web Date: January 30, 2014
NMR Structures Get Sharper With Rosetta
For determining protein structure, X-ray crystallography typically beats nuclear magnetic resonance spectroscopy for accuracy. But chemists now report that, in most cases, NMR structures refined by a computer program called Rosetta match more closely with those determined by crystallography than do unrefined ones.
Although X-ray crystallography is the gold standard for solving protein structures, not all proteins crystallize well. Also, floating in solution could be a more realistic condition for proteins than sitting in a . . .
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