Small Molecules Block Activity Of MicroRNA Transcription Factors | February 17, 2014 Issue - Vol. 92 Issue 7 | Chemical & Engineering News
Volume 92 Issue 7 | p. 9 | News of The Week
Issue Date: February 17, 2014

Small Molecules Block Activity Of MicroRNA Transcription Factors

Drug Discovery: Computational method identifies compound that blocks microRNA that normally silences lethal gene in cancer cells
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Organic SCENE
Keywords: microRNA, miRNA, antagomirs, cancer

Researchers have developed a computational method that identifies small molecules that block the function of microRNAs (miRNAs), which are important cellular targets for cancer and other diseases (Nat. Chem. Biol. 2014, DOI: 10.1038/nchembio.1452). One of the agents has a selective type of anticancer activity, suggesting that a drug based on it might have fewer side effects than conventional cancer chemotherapies.

miRNAs are three-dimensionally folded . . .

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