New Route To Improved Heparins | March 3, 2014 Issue - Vol. 92 Issue 9 | Chemical & Engineering News
 
 
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Volume 92 Issue 9 | p. 7 | News of The Week
Issue Date: March 3, 2014

New Route To Improved Heparins

Drug Discovery: Chemoenzymatic analogs may sidestep key problems of current anticoagulants
Department: Science & Technology
News Channels: Biological SCENE
Keywords: heparin, anticoagulant, thrombosis, clotting

Researchers have used chemoenzymatic synthesis to create new forms of heparin that may solve key problems with current versions of the medication. Heparin, a sugar-based polymer, is widely used to reduce blood clotting in patients who have thrombosis and other conditions.

Two of the three commercial forms of heparin—unfractionated heparin and low-molecular-weight heparin—are derived from pig intestines. That means they are inhomogeneous mixtures of sulfated carbohydrates of different sizes and variable sulfation patterns, leaving them . . .

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