Issue Date: March 3, 2014
New Route To Improved Heparins
Researchers have used chemoenzymatic synthesis to create new forms of heparin that may solve key problems with current versions of the medication. Heparin, a sugar-based polymer, is widely used to reduce blood clotting in patients who have thrombosis and other conditions.
Two of the three commercial forms of heparin—unfractionated heparin and low-molecular-weight heparin—are derived from pig intestines. That means they are inhomogeneous mixtures of sulfated carbohydrates of different sizes and variable sulfation patterns, leaving them . . .
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