Web Date: August 4, 2014
Hijacking Bacteria’s Heat-Shock Response Could Boost Protein Production
In academic and industrial labs, Escherichia coli happily churn out recombinant proteins for researchers. But in many cases, the microbes’ cellular machinery balks at this heavy labor and a large amount of the proteins end up misfolded in unusable clumps. To boost capacity, researchers incorporated a mutant transcription factor into bacteria that unleashes the microbes’ natural arsenal for fighting cellular stress (ACS Chem. Biol. 2014, DOI: . . .
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