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Web Date: August 4, 2014

Hijacking Bacteria’s Heat-Shock Response Could Boost Protein Production

Biotechnology: Researchers improved the solubility and activity of recombinant proteins by coexpressing them with a transcription factor that sparks cell repair
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: heat-shock response, recombinant proteins, chaperones, transcription factor

In academic and industrial labs, Escherichia coli happily churn out recombinant proteins for researchers. But in many cases, the microbes’ cellular machinery balks at this heavy labor and a large amount of the proteins end up misfolded in unusable clumps. To boost capacity, researchers incorporated a mutant transcription factor into bacteria that unleashes the microbes’ natural arsenal for fighting cellular stress (ACS Chem. Biol. 2014, DOI: . . .

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ISSN 0009-2347
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