Issue Date: June 22, 2015
Chemists Increasingly Consider Residence Time In Drug Design
In drug discovery, researchers think a lot about how tightly a small molecule binds to its target. For a long time, drug developers have considered tightly binding compounds better, more promising drug candidates than molecules that interact weakly with their targets. So improving binding affinities is a critical aspect of medicinal chemistry and drug design.
Recently, an alternative parameter called residence time—how long a drug remains bound to its target—has been attracting growing interest. Although . . .
To view the rest of this content, please log in with your ACS ID.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society