Volume 93 Issue 25 | pp. 36-37
Issue Date: June 22, 2015

Chemists Increasingly Consider Residence Time In Drug Design

Drug Discovery: Studies suggest duration of binding, not just affinity, may be a key factor
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: residence time, efficacy, drug design, inhibitors, enzymes

In drug discovery, researchers think a lot about how tightly a small molecule binds to its target. For a long time, drug developers have considered tightly binding compounds better, more promising drug candidates than molecules that interact weakly with their targets. So improving binding affinities is a critical aspect of medicinal chemistry and drug design.

Recently, an alternative parameter called residence time—how long a drug remains bound to its target—has been attracting growing interest. Although . . .

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