Volume 93 Issue 30 | p. 9 | News of The Week
Issue Date: July 27, 2015 | Web Date: July 23, 2015

Chemists Find A Simple Approach To Activating Amide C–N Bonds

Organic Synthesis: UCLA team develops a nickel-catalyzed method for cleaving and modifying the normally unreactive functional group
Department: Science & Technology
News Channels: Organic SCENE
Keywords: nickel catalyst, N-heterocyclic carbene, amide bond, ester synthesis, amine

Nature typically outdoes chemists when it comes to efficiently carrying out reactions. But for a nickel—or make that a simple nickel catalyst—a team of UCLA chemists has matched wits with enzymes on cleaving the C–N bond in amides. The achievement overcomes a classic problem of the low reactivity of amides and opens up this key family of compounds to broader use as synthetic building blocks.

Amides are the functional units that link amino acids together . . .

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