Volume 93 Issue 31 | p. 9 | News of The Week
Issue Date: August 3, 2015 | Web Date: July 30, 2015

Designer Ribosome Works In Live Cells

Synthetic Biology: Researchers engineer entire protein-making complex for first time
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: ribosome, large subunit, small subunit, protein translation, mRNA

Researchers have artificially engineered a complete ribosome—the cell-based machine that translates mRNA into proteins—in the laboratory.

The ability to engineer the ribosome not only could help scientists understand how the protein-maker works, but it also could endow the ribosome with new functions. For drug discovery and basic research, engineered ribosomes could create nonnatural proteins or even nonprotein polymers that would be difficult or impossible for native ribosomes to make.

Alexander Mankin of . . .

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