Issue Date: August 24, 2015 | Web Date: August 21, 2015
Pairing Two Catalysts Promotes Synthesis Of Unsymmetrical Biaryl Compounds
In a surprising twist on classical cross-coupling chemistry, a research team at the University of Rochester has discovered the first general method for making unsymmetrical biaryl compounds directly from two different aryl electrophiles.
The new approach, which involves using two metal catalysts to promote the aryl-aryl coupling of unwilling partners, is being hailed as a means of simplifying the synthesis of complex molecules such as pharmaceuticals. The approach also provides new insight into the selective . . .
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- Chemical & Engineering News
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