Volume 93 Issue 37 | p. 25 | Concentrates
Issue Date: September 21, 2015

Aromatic Approach To (+)-Batzelladine B

Natural Product Synthesis: By using pyrrole-based starting materials, chemists develop a streamlined strategy for anti-HIV alkaloid’s synthesis
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: batzellidine, nitrogen, heterocycles, natural products

First isolated from a Caribbean sponge 20 years ago, the batzelladine alkaloids have captured the imagination of chemists for two reasons: The compounds have powerful anti-HIV activity, and their complex structures provide an intriguing target to tackle with total synthesis. The structures are challenging to construct, however, because of their multiple basic nitrogen groups. These nucleophilic groups are prone to oxidation and tend to react in unexpected ways. Previous batzelladine syntheses that start with nonaromatic . . .

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