Volume 93 Issue 37 | p. 7 | News of The Week
Issue Date: September 21, 2015

Study Paints New Portrait Of Cell’s Response To Stress

Cell Biology: Protein aggregates formed during heat shock aren’t necessarily a death sentence
Department: Science & Technology
News Channels: Biological SCENE
Keywords: protein aggregation, heat shock, stress response

The textbook picture of what happens to proteins in cells stressed by heat might need to be redrawn, according to a new study (Cell 2015, DOI: 10.1016/j.cell.2015.08.041).

The conventional understanding is that misfolded and otherwise damaged proteins aggregate in response to heat shock. Those aggregated proteins need to be fixed or, if they can’t be fixed, degraded and disposed of.

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