Issue Date: September 28, 2015
Multi C–H Functionalizations
Developing C–H functionalization reactions is a major focus of organic chemistry research. But using different C–H functionalizations sequentially to streamline complex syntheses remains challenging. Houhua Li and Xiaoguang Lei of Peking University and the National Institute of Biological Sciences, both in Beijing, and coworkers have now used an unprecedented four C–H functionalization reactions as part of a 14-step first enantioselective total synthesis of the natural product (–)-incarviatone A (J. Am. Chem. Soc. . . .
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