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Business
Provepep Synthesizes Therapeutic Protein
by Ann M. Thayer
October 12, 2015
| A version of this story appeared in
Volume 93, Issue 40
Provepep, the peptide business of the French fine chemistry group Provence Technologies, says it has synthesized 10 mg of the bioactive homodimer form of interleukin-10, an anti-inflammatory cytokine. In doing so, it claims to be one of only a few labs able to chemically synthesize large therapeutic proteins. Provepep used solid-phase peptide synthesis to make segments of the protein and its bis(2-sulfanylethyl)amido ligation technology to join them into a 160 amino acid-long IL-10 subunit.
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