Volume 93 Issue 41 | p. 8 | News of The Week
Issue Date: October 19, 2015 | Web Date: October 15, 2015

New Technique Illuminates Small-Molecule Screening

Drug Discovery: Light not only detects cell signaling but also activates the pathway, easing inhibitor discovery
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: screening, receptor, signaling, light, drug discovery

Researchers have found an easier way to screen for molecules that inhibit signaling pathways in cells. The new method uses light at both ends, so to speak, to activate a signaling pathway and then announce whether signal propagation proceeded successfully.

The technique could speed screening for drug discovery because it doesn’t need synthetic small molecules or endogenous receptor ligands to activate pathways or added reporting agents to monitor signals. The assay also obviates the need . . .

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