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Web Date: December 30, 2015

Activating Protein Garbage Disposals Could Help Treat Alzheimer’s

Neuroscience: Small molecule keeps protein-degrading proteasomes active in mouse brains
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Alzheimer’s disease, tau, proteasome, protein aggregation

In neurodegenerative diseases, certain proteins misfold and clump up in the brain. For example, Alzheimer’s disease produces aggregates of amyloid-β and tau.

A new study in mice reports that aggregated tau can impair the function of proteasomes, garbage disposals that cells use to break down misfolded or damaged proteins. This impairment encourages more tau clumps to accumulate in the brain. Ramping up the activity of proteasomes with a small molecule overcame this impairment, leading to . . .

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Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society