Web Date: December 30, 2015
Activating Protein Garbage Disposals Could Help Treat Alzheimer’s
In neurodegenerative diseases, certain proteins misfold and clump up in the brain. For example, Alzheimer’s disease produces aggregates of amyloid-β and tau.
A new study in mice reports that aggregated tau can impair the function of proteasomes, garbage disposals that cells use to break down misfolded or damaged proteins. This impairment encourages more tau clumps to accumulate in the brain. Ramping up the activity of proteasomes with a small molecule overcame this impairment, leading to . . .
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