Volume 94 Issue 1 | p. 21 | Concentrates
Issue Date: January 4, 2016

Web: Targeting Protein Garbage Disposal To Treat Alzheimer’s

Neuroscience: Small molecule keeps protein-degrading proteasomes active in mouse brains
Department: Science & Technology
Keywords: Alzheimer’s disease, tau, proteasome, protein aggregation

In neurodegenerative diseases, certain proteins misfold and clump in the brain. A study of mice reports that aggregated tau—a protein associated with Alzheimer’s disease—can impair the function of cells’ proteasomes, garbage disposals that cells use to break down misfolded proteins. Ramping up the activity of proteasomes with a small molecule overcame this impairment, leading to fewer tau aggregates and improved cognitive function. Natura Myeku of Columbia University and colleagues studied genetically engineered mice that express . . .

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