Volume 94 Issue 13 | p. 8 | News of The Week
Issue Date: March 28, 2016 | Web Date: March 25, 2016

Z-alkenyl halides made easy

Tough-to-prepare motif succumbs to metathesis
Department: Science & Technology
News Channels: Organic SCENE
Keywords: synthesis, cross-metathesis, Z-alkenyl fluoride, perphenazine

One of organic chemists’ dirty little secrets, says Boston College’s Amir Hoveyda, is how hard it is to make alkenyl halides, a motif that features a halide attached to a double bond. “We use them all the time for cross-coupling,” he says, “but we never talk about how we make them.” The truth, Hoveyda says, is that making alkenyl bromides and chlorides is difficult, and making alkenyl fluorides is almost unheard . . .

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