Advertisement

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Materials

Newly Engineered Tissue Sheds Light On Fibrocartilage

Tissue Engineering: Study finds that the size, but not the number, of proteoglycan domains increases throughout development and aging

by Celia Henry Arnaud
January 11, 2016 | A version of this story appeared in Volume 94, Issue 2

[+]Enlarge
Credit: Woojin Han and Su Chin Heo
Heterogeneous tissue-engineered constructs reproduce the microstructural, micromechanical, and mechanobiological features of natural fibrocartilage. This image shows interactions between fibrous (red) and proteoglycan-rich (blue) microdomains.
Micrograph showing engineered fibrocartilage with fibrous and proteoglycan-rich domains.
Credit: Woojin Han and Su Chin Heo
Heterogeneous tissue-engineered constructs reproduce the microstructural, micromechanical, and mechanobiological features of natural fibrocartilage. This image shows interactions between fibrous (red) and proteoglycan-rich (blue) microdomains.

Fibrocartilage is a type of tissue, such as that in the knee meniscus, that consists of aligned fibrous microdomains with nonfibrous proteoglycan-rich microdomain inclusions. The role of these different domains in growth and development, aging, and disease is not well understood. Dawn M. Elliott of the University of Delaware, Robert L. Mauck of the University of Pennsylvania, and coworkers have now quantified the proteoglycan microdomains in knee fibrocartilage from fetal, juvenile, and adult cows and from adult humans and assessed the tissue’s response to strain (Nat. Mater. 2016, DOI: 10.1038/nmat4520). The number of proteoglycan microdomains reached a steady state at the juvenile stage, they found, but the size of the proteoglycan domains continued to increase throughout aging. In humans, the size, but not the number, of inclusions correlated with age, body mass index, and diagnosis of osteoarthritis. The researchers separately engineered fibrocartilage by seeding cells on a polymer scaffold. One type of cell deposits the collagen matrix, and another type of cell deposits proteoglycans. The mechanical and signaling response of the engineered tissue to tensile strain matched that of the natural tissue. The engineered tissue thus provides a new tool for scientists to develop treatments for disease or injury, the researchers conclude.

Article:

This article has been sent to the following recipient:

0 /1 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.