Volume 94 Issue 25 | p. 5 | News of The Week
Issue Date: June 20, 2016 | Web Date: June 17, 2016

Protein cages made in the lab resemble protective virus constructs

Self-assembled icosahedral structures might one day be used for drug packaging and delivery
Department: Science & Technology
News Channels: Biological SCENE, Nano SCENE
Keywords: structural biology, icosahedron, protein design

Viruses store their genetic material inside a protein shell, known as a capsid, which sometimes has an icosahedral shape. Now, in a development that could go viral, chemists have learned how to create protein icosahedra that look just like the ones some viruses use. Potential applications of such caged structures include packaging biomolecules, drugs, and vaccines and delivering displayed antigens capable of eliciting disease-fighting antibodies.

Yang Hsia and David Baker at the University of Washington . . .

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