Volume 94 Issue 29 | p. 8 | Concentrates
Issue Date: July 18, 2016

New technique images amyloid-β plaques in the brain in 3-D

Shapes of Alzheimer’s plaques differ in mice and people
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: neuroscience, Alzheimer’s disease, amyloid-β, microscopy, tissue clearing

Although amyloid-β plaques are one of the hallmarks of Alzheimer’s disease, scientists still don’t know what triggers the formation of the peptide clumps or what they do to surrounding brain tissue. A new technique that produces three-dimensional images of such plaques in mouse and human brains could help researchers start to answer those questions, say the method’s developers (Cell Rep. 2016, DOI: 10.1016/j.celrep.2016.06.060). . . .

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