Volume 94 Issue 37 | p. 8 | Concentrates
Issue Date: September 19, 2016

Designed peptides with constrained structures are good drug prospects

Computational modeling technique creates peptides with fixed, unprecedented shapes
Department: Science & Technology
News Channels: Biological SCENE
Keywords: computational chemistry, protein design, peptides, disulfide bonding, cyclization

A newly developed computational approach makes it possible to design peptides with defined three-dimensional structures that could be useful for drug discovery (Nature 2016, DOI: 10.1038/nature19791). Peptides are often too floppy and undisciplined to interact with molecular targets in a consistent way. But the designed peptides’ disulfide bonds and terminal cyclization constrain them into defined shapes that enhance their potential for bioactivity. Protein design generally relies . . .

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