Issue Date: September 19, 2016
Designed peptides with constrained structures are good drug prospects
A newly developed computational approach makes it possible to design peptides with defined three-dimensional structures that could be useful for drug discovery (Nature 2016, DOI: 10.1038/nature19791). Peptides are often too floppy and undisciplined to interact with molecular targets in a consistent way. But the designed peptides’ disulfide bonds and terminal cyclization constrain them into defined shapes that enhance their potential for bioactivity. Protein design generally relies . . .
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