Volume 94 Issue 40 | p. 11 | Concentrates
Issue Date: October 10, 2016

Fluoroamide fluorinates itself

In an iron-catalyzed process, the reagent acts as the fluorine source and provides its own directing group for late-stage C–H fluorinations
Department: Science & Technology
News Channels: Organic SCENE, JACS In C&EN
Keywords: fluorination, fluoroamide, radical reaction, directing group

When it comes to fluorination of C–H bonds, chemists typically select one reagent to supply the fluorine and must decide whether the target substrate molecule requires a directing group or not to help activate the desired C–H bond and point the fluorine in the right direction. Brian J. Groendyke, Deyaa I. AbuSalim, and Silas P. Cook of Indiana University, Bloomington, have reduced the number of decisions to be made by developing . . .

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