Volume 94 Issue 46 | p. 11 | Concentrates
Issue Date: November 21, 2016

Cannabinoid receptor revealed

Two research teams separately publish the first crystal structures of the CB1 receptor
Department: Science & Technology
Keywords: neuroscience, cannabinoid, CB1, cannabinoid receptor

Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and other physiological processes. The protein’s floppy movements between active and inactive states make it difficult to study, so Alexandros Makriyannis of Northeastern University and colleagues designed a strong inhibitor to bind and help immobilize CB1 to get a better glimpse of its structure (Cell . . .

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