Issue Date: November 21, 2016
Cannabinoid receptor revealed
Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and other physiological processes. The protein’s floppy movements between active and inactive states make it difficult to study, so Alexandros Makriyannis of Northeastern University and colleagues designed a strong inhibitor to bind and help immobilize CB1 to get a better glimpse of its structure (Cell . . .
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- Chemical & Engineering News
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