Volume 94 Issue 47 | p. 10 | Concentrates
Issue Date: November 28, 2016

Making the ‘crystalline sponge’ more user-friendly

Multiwell microplate protocol boosts yields of quality crystals for X-ray analysis and cuts down on experiment time
Department: Science & Technology
News Channels: Organic SCENE, Materials SCENE
Keywords: analytical chemistry, crystalline sponge, multiwell microplate

In 2013, when University of Tokyo’s Makoto Fujita reported a way to determine a complex molecule’s X-ray crystal structure without having to actually crystallize the molecule in question, the technique was hailed as a breakthrough for structural determination. But the technique, known as the “crystalline sponge” method because guest molecules soak into a metal-organic framework crystal where they orient themselves in a way that their structure can be determined via X-ray analysis, has yet to . . .

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